{"metadata":{"accession":"PF13652","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025203","hierarchy":null,"name":{"name":"Putative quorum-sensing-regulated virulence factor","short":"QSregVF"},"description":[{"text":"<p>This is a family of short ~14 kDa proteins from Psuedomonas. The structure of UniProtKB:Q9HY15 a secreted protein has been solved and deposited as PDB:3npd. It comprises one structural domain with five beta-strands and five alpha-helices. Various comparative structural prediction methods plus its genomic location point to the protein forming a functional dimer with its adjacent genomic partner, UniProtKB:Q9HY14, in [pfam:PF12843]. Together these might be regulated by the other product from the PotABCD operon, namely the putrescine-binding periplasmic protein UniProtKB:Q9HY16. which has been implicated in quorum-sensing. QSregVF is certainly up-regulated in quorum-sensing, and is predicted to be a virulence factor [[cite:PUB00075641]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075641":{"PMID":24174223,"ISBN":null,"volume":"82","issue":"6","year":2014,"title":"Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family.","URL":null,"raw_pages":"1086-92","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Das D","Chiu HJ","Farr CL","Grant JC","Jaroszewski L","Knuth MW","Miller MD","Tien HJ","Elsliger MA","Deacon AM","Godzik A","Lesley SA","Wilson IA."],"DOI_URL":"http://dx.doi.org/10.1002/prot.24455"}},"set_info":{"accession":"CL0940","name":"AspS-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":432,"pathways":0,"proteins":432,"proteomes":430,"sets":1,"structural_models":{"alphafold":240},"structures":1,"taxa":489},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":77},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3npd","name":"Crystal structure of a putative secreted protein (PA3611) from PSEUDOMONAS AERUGINOSA at 1.60 A resolution"}}}