{"metadata":{"accession":"PF13605","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025415","hierarchy":null,"name":{"name":"Domain of unknown function (DUF4141)","short":"DUF4141"},"description":[{"text":"<p>Based on Bacteroides thetaiotaomicron gene BT_4772, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [[cite:PUB00056011],[cite:PUB00056012]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00056012":{"PMID":16735464,"ISBN":null,"volume":"103","issue":"23","year":2006,"title":"A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism.","URL":null,"raw_pages":"8834-9","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Sonnenburg ED","Sonnenburg JL","Manchester JK","Hansen EE","Chiang HC","Gordon JI."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0603249103"},"PUB00056011":{"PMID":15790854,"ISBN":null,"volume":"307","issue":"5717","year":2005,"title":"Glycan foraging in vivo by an intestine-adapted bacterial symbiont.","URL":null,"raw_pages":"1955-9","medline_journal":"Science","ISO_journal":"Science","authors":["Sonnenburg JL","Xu J","Leip DD","Chen CH","Westover BP","Weatherford J","Buhler JD","Gordon JI."],"DOI_URL":"http://dx.doi.org/10.1126/science.1109051"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":889,"pathways":0,"proteins":889,"proteomes":545,"sets":0,"structural_models":{"alphafold":604},"structures":0,"taxa":890},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":409},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}