{"metadata":{"accession":"PF13491","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025199","hierarchy":null,"name":{"name":"4TM region of DNA translocase FtsK/SpoIIIE","short":"FtsK_4TM"},"description":[{"text":"<p>4TM_FtsK is the integral membrane domain of the FtsK DNA tranlocases. During sporulation in Bacillus subtilis, the SpoIIIE protein is believed to form a translocation pore at the leading edge of the nearly closed septum. The E. coli FtsK protein is homologous to SpoIIIE, and can free chromosomes trapped in vegetative septa.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00041884":{"PMID":17057717,"ISBN":null,"volume":"13","issue":"11","year":2006,"title":"The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS.","URL":null,"raw_pages":"965-72","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Sivanathan V","Allen MD","de Bekker C","Baker R","Arciszewska LK","Freund SM","Bycroft M","Lowe J","Sherratt DJ."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb1158"},"PUB00049695":{"PMID":18722176,"ISBN":null,"volume":"31","issue":"4","year":2008,"title":"Molecular mechanism of sequence-directed DNA loading and translocation by FtsK.","URL":null,"raw_pages":"498-509","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Lowe J","Ellonen A","Allen MD","Atkinson C","Sherratt DJ","Grainge I."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2008.05.027"},"PUB00041785":{"PMID":16916635,"ISBN":null,"volume":"23","issue":"4","year":2006,"title":"Double-stranded DNA translocation: structure and mechanism of hexameric FtsK.","URL":null,"raw_pages":"457-69","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Massey TH","Mercogliano CP","Yates J","Sherratt DJ","Lowe J."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2006.06.019"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":13056,"pathways":0,"proteins":13056,"proteomes":12945,"sets":0,"structural_models":{"alphafold":8415},"structures":0,"taxa":18378},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":43,"alignment:full":6687},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}