{"metadata":{"accession":"PF13355","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025344","hierarchy":null,"name":{"name":"ARC6-like, IMS domain","short":"ARC6-like_IMS"},"description":[{"text":"<p>This domain corresponds to the C-terminal intermembrane space (IMS) region from protein accumulation and replication of chloroplasts 6 (ARC6) and its paralogue PARC6 [[cite:PUB00096838]]. ARC6 and PARC6 are components of the plastid division machinery which are essential for the chloroplast replication process [[cite:PUB00096838],[cite:PUB00096839]], which implies the assembly and constriction of the tubulin-like FtsZ ring on the stromal surface of the inner envelope membrane (IEM) and the dynamin-like ARC5 ring on the cytosolic surface of the outer envelope membrane (OEM). ARC6 is evolutionarily related to the cyanobacterial cell division protein Ftn2/ZipN [[cite:PUB00096838]], having similar structures. This domain from ARC6 and PARC6 interacts with PDV2 and PDV1 respectively. PDV proteins recruit dynamin-like ARC5 ring to the chloroplast surface and mediates its constriction. ARC6/PARC6 are key to connect and coordinate Fst and ARC5 rings during fission [[cite:PUB00096837],[cite:PUB00096840]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00096837":{"PMID":18812496,"ISBN":null,"volume":"20","issue":"9","year":2008,"title":"Arabidopsis ARC6 coordinates the division machineries of the inner and outer chloroplast membranes through interaction with PDV2 in the intermembrane space.","URL":null,"raw_pages":"2460-70","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Glynn JM","Froehlich JE","Osteryoung KW."],"DOI_URL":null},"PUB00096840":{"PMID":32010156,"ISBN":null,"volume":"10","issue":null,"year":2019,"title":"Arabidopsis PARC6 Is Critical for Plastid Morphogenesis in Pavement, Trichome, and Guard Cells in Leaf Epidermis.","URL":null,"raw_pages":"1665","medline_journal":"Front Plant Sci","ISO_journal":"Front Plant Sci","authors":["Ishikawa H","Yasuzawa M","Koike N","Sanjaya A","Moriyama S","Nishizawa A","Matsuoka K","Sasaki S","Kazama Y","Hayashi Y","Abe T","Fujiwara MT","Itoh RD."],"DOI_URL":null},"PUB00096838":{"PMID":26452626,"ISBN":null,"volume":"25","issue":"2","year":2016,"title":"Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6.","URL":null,"raw_pages":"523-9","medline_journal":"Protein Sci","ISO_journal":"Protein Sci","authors":["Kumar N","Radhakrishnan A","Su CC","Osteryoung KW","Yu EW."],"DOI_URL":null},"PUB00096839":{"PMID":26527658,"ISBN":null,"volume":"170","issue":"1","year":2016,"title":"Roles of Arabidopsis PARC6 in Coordination of the Chloroplast Division Complex and Negative Regulation of FtsZ Assembly.","URL":null,"raw_pages":"250-62","medline_journal":"Plant Physiol","ISO_journal":"Plant Physiol","authors":["Zhang M","Chen C","Froehlich JE","TerBush AD","Osteryoung KW."],"DOI_URL":null}},"set_info":{"accession":"CL0051","name":"NTF2"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":42,"interactions":0,"matches":1587,"pathways":0,"proteins":1579,"proteomes":668,"sets":1,"structural_models":{"alphafold":1214},"structures":7,"taxa":1893},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":70,"alignment:full":1041},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}