{"metadata":{"accession":"PF13351","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025343","hierarchy":null,"name":{"name":"Protein of unknown function (DUF4099)","short":"DUF4099"},"description":[{"text":"<p>A family of uncharacterized proteins found by clustering human gut metagenomic sequences [[cite:PUB00055601]]. The C-terminal repeat region of this family is DUF4098, [pfam:PF13345].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00055601":{"PMID":20532204,"ISBN":null,"volume":"6","issue":"6","year":2010,"title":"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families.","URL":null,"raw_pages":"e1000798","medline_journal":"PLoS Comput Biol","ISO_journal":"PLoS Comput. Biol.","authors":["Ellrott K","Jaroszewski L","Li W","Wooley JC","Godzik A."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pcbi.1000798"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":1271,"pathways":0,"proteins":1269,"proteomes":610,"sets":0,"structural_models":{"alphafold":878},"structures":0,"taxa":843},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":20,"alignment:full":587},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}