{"metadata":{"accession":"PF13337","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR014061","hierarchy":null,"name":{"name":"Lon-like protease BrxL-like, ATPase domain","short":"BrxL_ATPase"},"description":[{"text":"<p>This entry represents the ATPase domain found in BREX system Lon protease-like protein BrxL from Bacillus cereus and similar proteins. BrxL is part of a type 1 BREX system which contains a C-terminal Lon-like protease domain ([pfam:PF05362]. BREX systems (bacteriophage exclusion) provide immunity against bacteriophage, a system that allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA [[cite:PUB00093365]]. Methylation of bacterial DNA by PglX probably guides self/non-self discrimination. This entry also includes a few uncharacterised viral sequences.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093365":{"PMID":25452498,"ISBN":null,"volume":"34","issue":"2","year":2015,"title":"BREX is a novel phage resistance system widespread in microbial genomes.","URL":null,"raw_pages":"169-83","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Goldfarb T","Sberro H","Weinstock E","Cohen O","Doron S","Charpak-Amikam Y","Afik S","Ofir G","Sorek R."],"DOI_URL":null}},"set_info":{"accession":"CL0023","name":"P-loop_NTPase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":16,"interactions":0,"matches":2169,"pathways":0,"proteins":2168,"proteomes":1189,"sets":1,"structural_models":{"alphafold":1751,"bfvd":2},"structures":2,"taxa":3559},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":744},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}