{"metadata":{"accession":"PF13320","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025150","hierarchy":null,"name":{"name":"Glycoside hydrolase 123, catalytic domain","short":"GH123_cat"},"description":[{"text":"<p>This domain is found at the C terminus of protein members of the glycoside hydrolase family 123, including N-acetylgalactosaminidase from Clostridium perfringens. This enzyme removes specific terminal N-D-acetylgalactosamine from glycosphingolipids. This catalytic domain adopts an alpha/beta barrel configuration with a two-stranded beta sheet and a pair of alpha-helices at the C-terminal end [[cite:PUB00100654],[cite:PUB00151590]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151590":{"PMID":27546776,"ISBN":null,"volume":"52","issue":"74","year":2016,"title":"Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighbouring group participation.","URL":null,"raw_pages":"11096-9","medline_journal":"Chem Commun (Camb)","ISO_journal":"Chem Commun (Camb)","authors":["Roth C","Petricevic M","John A","Goddard-Borger ED","Davies GJ","Williams SJ."],"DOI_URL":null},"PUB00100654":{"PMID":27038508,"ISBN":null,"volume":"428","issue":"16","year":2016,"title":"The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens.","URL":null,"raw_pages":"3253-3265","medline_journal":"J Mol Biol","ISO_journal":"J Mol Biol","authors":["Noach I","Pluvinage B","Laurie C","Abe KT","Alteen MG","Vocadlo DJ","Boraston AB."],"DOI_URL":null}},"set_info":{"accession":"CL0036","name":"TIM_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":151,"interactions":0,"matches":2177,"pathways":0,"proteins":2146,"proteomes":1422,"sets":1,"structural_models":{"alphafold":1398},"structures":19,"taxa":2901},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":1231},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8k2m","name":"Crystal structure of Group 4 Monosaccharide-releasing beta-N-acetylgalactosaminidase NgaP2 from Paenibacillus sp. TS12 in complex with GalNAc-thiazoline"}}}