{"metadata":{"accession":"PF13297","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025086","hierarchy":null,"name":{"name":"Replication stress response SDE2 C-terminal","short":"SDE2_2C"},"description":[{"text":"<p>This domain represents the C-terminal region of the Replication stress response SDE2, a genome surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in DNA repair. SDE2 C-terminal domain must be cleaved from its N-terminal at a diglycine motif within the ubiquitin-like fold, after Proliferating cell nuclear antigen (PCNA) interaction. This generates a functional protein that negatively regulates damage-inducible PCNA monoubiquitination, which then is proteolytically degraded to allow S phase progression and replication fork recovery in response to DNA damage [[cite:PUB00101934]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101934":{"PMID":27906959,"ISBN":null,"volume":"12","issue":"12","year":2016,"title":"PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress.","URL":null,"raw_pages":"e1006465","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet","authors":["Jo U","Cai W","Wang J","Kwon Y","D'Andrea AD","Kim H."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":78,"interactions":0,"matches":4067,"pathways":0,"proteins":4063,"proteomes":1782,"sets":0,"structural_models":{"alphafold":3532},"structures":50,"taxa":5538},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":43,"alignment:full":3034},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}