{"metadata":{"accession":"PF13281","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025136","hierarchy":null,"name":{"name":"MAP3K TRAFs-binding domain","short":"MAP3K_TRAF_bd"},"description":[{"text":"<p>This entry corresponds to the TNF receptor-associated factors (TRAFs)-binding domain found at the N-terminus of some MAP3Ks, like Apoptosis signal-regulating kinases (ASK). This domain is flanked by a thioredoxin-binding domain and a PH-like domain. It includes seven tetratricopeptide repeats (TPRs) and, together with the PH-like domain, constitutes the central regulatory domain of ASK1 [[cite:PUB00094650]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00094650":{"PMID":28242696,"ISBN":null,"volume":"114","issue":"11","year":2017,"title":"Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.","URL":null,"raw_pages":"E2096-E2105","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Weijman JF","Kumar A","Jamieson SA","King CM","Caradoc-Davies TT","Ledgerwood EC","Murphy JM","Mace PD."],"DOI_URL":null}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":83,"interactions":0,"matches":4348,"pathways":0,"proteins":4193,"proteomes":1297,"sets":1,"structural_models":{"alphafold":1768},"structures":2,"taxa":4235},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":3427},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}