This presumed domain is functionally uncharacterised. This protein region family is found in fungi, and is typically between 384 and 430 amino acids in length. These proteins are largely disordered with small regions of high conservation that are likely acting as short linear motifs. Some members of this family contain gelsolin domains at the C-terminus.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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