{"metadata":{"accession":"PF13165","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR023975","hierarchy":null,"name":{"name":"Six-cysteine peptide SCIFF","short":"SCIFF"},"description":[{"text":"<p>Members of this protein family are essentially universal in the class Clostidia and therefore highly abundant in the  human gut microbiome. This short peptide is designated  SCIFF, for Six Cysteines in Forty-Five residues. It is a  presumed ribosomal natural product precursor, always  found associated with a yet-uncharacterised radical SAM  protein that resembles other peptide modification radical  SAM enzymes and is designated SCIFF radical SAM maturase [[cite:PUB00055953]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00055953":{"PMID":21478363,"ISBN":null,"volume":"193","issue":"11","year":2011,"title":"Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification.","URL":null,"raw_pages":"2745-55","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Haft DH","Basu MK."],"DOI_URL":"http://dx.doi.org/10.1128/JB.00040-11"},"PUB00083698":{"PMID":27007615,"ISBN":null,"volume":"55","issue":"14","year":2016,"title":"Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-L-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link.","URL":null,"raw_pages":"2122-34","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Bruender NA","Wilcoxen J","Britt RD","Bandarian V."],"DOI_URL":"http://dx.doi.org/10.1021/acs.biochem.6b00145"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":983,"pathways":0,"proteins":980,"proteomes":974,"sets":0,"structural_models":{"alphafold":672},"structures":0,"taxa":1678},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":696},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}