{"metadata":{"accession":"PF13072","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR025177","hierarchy":null,"name":{"name":"Mother cell inhibitor of FtsZ","short":"MciZ"},"description":[{"text":"<p>This family of proteins is found in bacteria. Family members are approximately 40 amino acids in length. There is a conserved GKAW sequence motif. There is a single completely conserved residue G that may be functionally important. Family members include the Bacillus subtilis cell-division inhibitor, MciZ (mother cell inhibitor of FtsZ) which blocks the assembly of FtsZ. FtsZ (filamentation temperature-sensitive Z) is the bacterial homolog of tubulin. Crystal structure reveals that MciZ binds to the C-terminal polymerization interface of FtsZ, the equivalent of the minus end of tubulin, causing shortening of protofilaments and blocking the assembly of higher-order FtsZ structures. Hence, MciZ provides a capping-based regulatory mechanism for FtsZ [[cite:PUB00091017]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091017":{"PMID":25848052,"ISBN":null,"volume":"112","issue":"17","year":2015,"title":"FtsZ filament capping by MciZ, a developmental regulator of bacterial division.","URL":null,"raw_pages":"E2130-8","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Bisson-Filho AW","Discola KF","Castellen P","Blasios V","Martins A","Sforca ML","Garcia W","Zeri AC","Erickson HP","Dessen A","Gueiros-Filho FJ."],"DOI_URL":"https://doi.org/10.1073/pnas.1414242112"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":471,"pathways":0,"proteins":471,"proteomes":469,"sets":0,"structural_models":{"alphafold":273},"structures":2,"taxa":610},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":230},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}