{"metadata":{"accession":"PF12986","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024617","hierarchy":null,"name":{"name":"Domain of unknown function (DUF3870)","short":"DUF3870"},"description":[{"text":"<p>A family based on the C-terminal domain of 3KOG which shows structural similarity to pore-forming proteins [[cite:PUB00031944]][[cite:PUB00032169]], suggesting it may have a lytic function.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00031944":{"PMID":15258571,"ISBN":null,"volume":"11","issue":"8","year":2004,"title":"Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin.","URL":null,"raw_pages":"797-8","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Cole AR","Gibert M","Popoff M","Moss DS","Titball RW","Basak AK."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb804"},"PUB00032169":{"PMID":15687495,"ISBN":null,"volume":"280","issue":"17","year":2005,"title":"Structural analysis of the Laetiporus sulphureus hemolytic pore-forming lectin in complex with sugars.","URL":null,"raw_pages":"17251-9","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Mancheno JM","Tateno H","Goldstein IJ","Martinez-Ripoll M","Hermoso JA."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M413933200"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":1031,"pathways":0,"proteins":1031,"proteomes":744,"sets":0,"structural_models":{"alphafold":638},"structures":0,"taxa":1163},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":22,"alignment:full":500},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}