{"metadata":{"accession":"PF12969","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024618","hierarchy":null,"name":{"name":"Domain of Unknown Function with PDB structure (DUF3857)","short":"DUF3857"},"description":[{"text":"<p>This family is based on the first domain of the PDB structure PDB:3KD4(residues 1-228). It is structurally similar to domains in other hydrolases, eg. M1 family aminopeptidase (3ebi, Z=10, rmsd 3.6A for 152 CA, seq id 12%), despite lack of any significant sequence similarity.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0672","name":"p35"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":130,"interactions":0,"matches":6053,"pathways":0,"proteins":6025,"proteomes":2859,"sets":1,"structural_models":{"alphafold":3776},"structures":1,"taxa":4180},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":70,"alignment:full":2914},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}