A family of uncharacterised proteins found by clustering human gut metagenomic sequences [[cite:PUB00055601]]. This domain is likely to be related to the Toprim domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00055601":{"PMID":20532204,"ISBN":null,"volume":"6","issue":"6","year":2010,"title":"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families.","URL":null,"raw_pages":"e1000798","medline_journal":"PLoS Comput Biol","ISO_journal":"PLoS Comput. Biol.","authors":["Ellrott K","Jaroszewski L","Li W","Wooley JC","Godzik A."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pcbi.1000798"}},"set_info":{"accession":"CL0413","name":"Toprim-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":31,"interactions":0,"matches":869,"pathways":0,"proteins":859,"proteomes":412,"sets":1,"structural_models":{"alphafold":522},"structures":0,"taxa":1132},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":53,"alignment:full":588},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}