The search results from NCBI sequence alignment indicates a conserved domain belonging to ASCH superfamily [[cite:PUB00044668]]. Dali searching results show that the protein is a structurally similar to the PUA domain, suggesting it may be involved in RNA recognition. It has been reported that the deletion of PUA genes results in impaired growth (RluD) and competitive disadvantage (TruB) in Escherichia coli. Suggestions have been put forward that, apart from their usual catalytic role, certain PUS enzymes (e.g. TruB) may also act as chaperones for RNA folding. The interface interaction indicates that the biomolecule of protein NP_809782.1 should be a dimer.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00044668":{"PMID":16322048,"ISBN":null,"volume":"22","issue":"3","year":2006,"title":"The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism.","URL":null,"raw_pages":"257-63","medline_journal":"Bioinformatics","ISO_journal":"Bioinformatics","authors":["Iyer LM","Burroughs AM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1093/bioinformatics/bti767"}},"set_info":{"accession":"CL0178","name":"PUA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":604,"pathways":0,"proteins":604,"proteomes":544,"sets":1,"structural_models":{"alphafold":282},"structures":1,"taxa":1185},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":289},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3iuw","name":"Crystal structure of Activating signal cointegrator (NP_814290.1) from ENTEROCOCCUS FAECALIS V583 at 1.58 A resolution"}}}