Member PDB:3GF6 has statistically significant similarity to TNF-like jelly roll fold may indicate an immunomodulatory function[[cite:PUB00055998]] or a bioadhesion role[[cite:PUB00055999]]
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00055998":{"PMID":20346680,"ISBN":null,"volume":"35","issue":"8","year":2010,"title":"The molecular regulation of programmed necrotic cell injury.","URL":null,"raw_pages":"434-41","medline_journal":"Trends Biochem Sci","ISO_journal":"Trends Biochem. Sci.","authors":["Moquin D","Chan FK."],"DOI_URL":"http://dx.doi.org/10.1016/j.tibs.2010.03.001"},"PUB00055999":{"PMID":20152153,"ISBN":null,"volume":"18","issue":"1","year":2010,"title":"A TNF-like trimeric lectin domain from Burkholderia cenocepacia with specificity for fucosylated human histo-blood group antigens.","URL":null,"raw_pages":"59-72","medline_journal":"Structure","ISO_journal":"Structure","authors":["Sulak O","Cioci G","Delia M","Lahmann M","Varrot A","Imberty A","Wimmerova M."],"DOI_URL":"http://dx.doi.org/10.1016/j.str.2009.10.021"}},"set_info":{"accession":"CL0100","name":"C1q_TNF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":17,"pathways":0,"proteins":17,"proteomes":17,"sets":1,"structural_models":{"alphafold":13},"structures":1,"taxa":31},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":7},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3gf6","name":"Crystal structure of a bacterial lipoprotein (bt_1233) from bacteroides thetaiotaomicron vpi-5482 at 1.69 A resolution"}}}