{"metadata":{"accession":"PF12842","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024557","hierarchy":null,"name":{"name":"CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819","short":"DUF3819"},"description":[{"text":"<p>This is an uncharacterised domain that is found on the CCR4-Not complex component Not1. Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID [[cite:PUB00010586]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00010586":{"PMID":11696541,"ISBN":null,"volume":"277","issue":"4","year":2002,"title":"Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase.","URL":null,"raw_pages":"2835-42","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Maillet L","Collart MA."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M107979200"},"PUB00088315":{"PMID":24121232,"ISBN":null,"volume":"20","issue":"11","year":2013,"title":"Structure and assembly of the NOT module of the human CCR4-NOT complex.","URL":null,"raw_pages":"1289-97","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Boland A","Chen Y","Raisch T","Jonas S","Kuzuoglu-Ozturk D","Wohlbold L","Weichenrieder O","Izaurralde E."],"DOI_URL":"https://doi.org/10.1038/nsmb.2681"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":202,"interactions":0,"matches":5351,"pathways":0,"proteins":5334,"proteomes":3046,"sets":0,"structural_models":{"alphafold":297},"structures":7,"taxa":8104},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":111,"alignment:full":3985},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4ct7","name":"CNOT9-CNOT1 complex with bound tryptophan"}}}