{"metadata":{"accession":"PF12618","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022255","hierarchy":null,"name":{"name":"PHD finger protein 20, AT-hook","short":"PHF20_AT-hook"},"description":[{"text":"<p>PHD finger protein 20 (PHF20) is a Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. It consists of tandem Tudor domains at the N-terminal, an AT hook, a C2H2-type zinc finger, and a plant homeodomain (PHD) finger [[cite:PUB00059425],[cite:PUB00094038],[cite:PUB00061037]]. This entry represents the AT-hook domain, a putative DNA-binding domain [[cite:PUB00059425],[cite:PUB00094038],[cite:PUB00061037]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00061037":{"PMID":22864287,"ISBN":null,"volume":null,"issue":null,"year":2012,"title":"PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.","URL":null,"raw_pages":null,"medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Cui G","Park S","Badeaux AI","Kim D","Lee J","Thompson JR","Yan F","Kaneko S","Yuan Z","Botuyan MV","Bedford MT","Cheng JQ","Mer G."],"DOI_URL":null},"PUB00059425":{"PMID":22449972,"ISBN":null,"volume":"586","issue":"6","year":2012,"title":"Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins.","URL":null,"raw_pages":"859-65","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett.","authors":["Adams-Cioaba MA","Li Z","Tempel W","Guo Y","Bian C","Li Y","Lam R","Min J."],"DOI_URL":"http://dx.doi.org/10.1016/j.febslet.2012.02.012"},"PUB00094038":{"PMID":24492612,"ISBN":null,"volume":"289","issue":"12","year":2014,"title":"Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.","URL":null,"raw_pages":"8277-87","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Esteve PO","Terragni J","Deepti K","Chin HG","Dai N","Espejo A","Correa IR Jr","Bedford MT","Pradhan S."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":781,"pathways":0,"proteins":781,"proteomes":508,"sets":0,"structural_models":{"alphafold":689},"structures":0,"taxa":1509},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":676},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}