Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with [pfam:PF00560] [[cite:PUB00075689]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Pannexin","extract":"Pannexins are a family of vertebrate proteins identified by their homology to the invertebrate innexins. While innexins are responsible for forming gap junctions in invertebrates, the pannexins have been shown to predominantly exist as large transmembrane channels connecting the intracellular and extracellular space, allowing the passage of ions and small molecules between these compartments.
","thumbnail":null}],"literature":{"PUB00075689":{"PMID":22532330,"ISBN":null,"volume":"34","issue":"7","year":2012,"title":"LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.","URL":null,"raw_pages":"551-60","medline_journal":"Bioessays","ISO_journal":"Bioessays","authors":["Abascal F","Zardoya R."],"DOI_URL":"http://dx.doi.org/10.1002/bies.201100173"}},"set_info":{"accession":"CL0375","name":"Transporter"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":114,"interactions":0,"matches":4478,"pathways":0,"proteins":4357,"proteomes":773,"sets":1,"structural_models":{"alphafold":3834},"structures":49,"taxa":2372},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":3649},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}