This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas [[cite:PUB00075175]]. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes [[cite:PUB00098180]]. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants [[cite:PUB00098179]]. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts [[cite:PUB00098181]]. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098180":{"PMID":16183838,"ISBN":null,"volume":"139","issue":"2","year":2005,"title":"Mutation of the RESURRECTION1 locus of Arabidopsis reveals an association of cuticular wax with embryo development.","URL":null,"raw_pages":"909-19","medline_journal":"Plant Physiol","ISO_journal":"Plant Physiol","authors":["Chen X","Goodwin SM","Liu X","Chen X","Bressan RA","Jenks MA."],"DOI_URL":null},"PUB00075175":{"PMID":22427331,"ISBN":null,"volume":"135","issue":"Pt 4","year":2012,"title":"KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas.","URL":null,"raw_pages":"1027-41","medline_journal":"Brain","ISO_journal":"Brain","authors":["Brockschmidt A","Trost D","Peterziel H","Zimmermann K","Ehrler M","Grassmann H","Pfenning PN","Waha A","Wohlleber D","Brockschmidt FF","Jugold M","Hoischen A","Kalla C","Waha A","Seifert G","Knolle PA","Latz E","Hans VH","Wick W","Pfeifer A","Angel P","Weber RG."],"DOI_URL":"http://dx.doi.org/10.1093/brain/aws045"},"PUB00098181":{"PMID":31076735,"ISBN":null,"volume":"5","issue":"5","year":2019,"title":"A genetics screen highlights emerging roles for CPL3, RST1 and URT1 in RNA metabolism and silencing.","URL":null,"raw_pages":"539-550","medline_journal":"Nat Plants","ISO_journal":"Nat Plants","authors":["Li T","Natran A","Chen Y","Vercruysse J","Wang K","Gonzalez N","Dubois M","Inze D."],"DOI_URL":null},"PUB00098179":{"PMID":31455787,"ISBN":null,"volume":"10","issue":"1","year":2019,"title":"RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis.","URL":null,"raw_pages":"3871","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Lange H","Ndecky SYA","Gomez-Diaz C","Pflieger D","Butel N","Zumsteg J","Kuhn L","Piermaria C","Chicher J","Christie M","Karaaslan ES","Lang PLM","Weigel D","Vaucheret H","Hammann P","Gagliardi D."],"DOI_URL":null}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":38,"interactions":0,"matches":2822,"pathways":0,"proteins":2311,"proteomes":1335,"sets":1,"structural_models":{"alphafold":506},"structures":0,"taxa":4349},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":27,"alignment:full":1995},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}