This entry represents a protein domain found in fungi. This domain is frequently encoded within Starship elements, which are large transposable elements that mobilise accessory genes in fungal genomes [[cite:PUB00163731]]. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00163731":{"PMID":37023132,"ISBN":null,"volume":"120","issue":"15","year":2023,"title":"Starships are active eukaryotic transposable elements mobilized by a new family of tyrosine recombinases.","URL":null,"raw_pages":"e2214521120","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Urquhart AS","Vogan AA","Gardiner DM","Idnurm A."],"DOI_URL":"https://doi.org/10.1073/pnas.2214521120"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":46,"interactions":0,"matches":1857,"pathways":0,"proteins":1644,"proteomes":486,"sets":0,"structural_models":{"alphafold":1314},"structures":0,"taxa":1022},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":1753},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}