{"metadata":{"accession":"PF12505","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022185","hierarchy":null,"name":{"name":"Protein of unknown function (DUF3712)","short":"DUF3712"},"description":[{"text":"<p>This domain family is found in fungi, and is approximately 130 amino acids in length. This domain showed a distant similarity to LEA-2 domains [[cite:PUB00100166]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00100166":{"PMID":34347309,"ISBN":null,"volume":"90","issue":"1","year":2022,"title":"TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.","URL":null,"raw_pages":"164-175","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Levine TP."],"DOI_URL":null}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":55,"interactions":0,"matches":4862,"pathways":0,"proteins":2881,"proteomes":1187,"sets":1,"structural_models":{"alphafold":2048},"structures":0,"taxa":2520},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":56,"alignment:full":4301},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}