{"metadata":{"accession":"PF12480","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022168","hierarchy":null,"name":{"name":"Golgi associated RAB2 interactor protein-like, Rab2B-binding domain","short":"GARIL_Rab2_bd"},"description":[{"text":"<p>This domain is found in Golgi associated RAB2 interactor proteins and it is likely a Rab2B-binding domain [[cite:PUB00100833],[cite:PUB00100832],[cite:PUB00100834]]. Some members included in this entry, such as GAR1A/B and GAR2, are RAB2B effector proteins required for accurate acrosome formation and normal male fertility [[cite:PUB00100833],[cite:PUB00100834]]. GARI-L4 is a RAB2B effector protein required for the compacted Golgi morphology [[cite:PUB00100832]]. GARIL5 is a Rab2B effector protein which promotes cytosolic DNA-induced innate immune responses [[cite:PUB00100835]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100835":{"PMID":28930687,"ISBN":null,"volume":"20","issue":"12","year":2017,"title":"The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.","URL":null,"raw_pages":"2944-2954","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Takahama M","Fukuda M","Ohbayashi N","Kozaki T","Misawa T","Okamoto T","Matsuura Y","Akira S","Saitoh T."],"DOI_URL":null},"PUB00100832":{"PMID":26209634,"ISBN":null,"volume":"290","issue":"36","year":2015,"title":"Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.","URL":null,"raw_pages":"22250-61","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Aizawa M","Fukuda M."],"DOI_URL":null},"PUB00100834":{"PMID":34714330,"ISBN":null,"volume":"148","issue":"21","year":2021,"title":"FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.","URL":null,"raw_pages":null,"medline_journal":"Development","ISO_journal":"Development","authors":["Morohoshi A","Miyata H","Oyama Y","Oura S","Noda T","Ikawa M."],"DOI_URL":null},"PUB00100833":{"PMID":29025071,"ISBN":null,"volume":"32","issue":"11","year":2017,"title":"The expression characteristics of FAM71D and its association with sperm motility.","URL":null,"raw_pages":"2178-2187","medline_journal":"Hum Reprod","ISO_journal":"Hum Reprod","authors":["Ma Q","Li Y","Luo M","Guo H","Lin S","Chen J","Du Y","Jiang Z","Gui Y."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":34,"interactions":0,"matches":2570,"pathways":0,"proteins":2442,"proteomes":325,"sets":0,"structural_models":{"alphafold":1670},"structures":0,"taxa":1056},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":37,"alignment:full":2099},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}