{"metadata":{"accession":"PF12421","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021034","hierarchy":null,"name":{"name":"Tip attachment protein J, C-terminal receptor binding domain","short":"Ig_GpJ_C"},"description":[{"text":"<p>This entry represents the C-terminal receptor binding domain of Tip attachment protein J from Escherichia phage lambda (GpJ) and similar bacterial and viral proteins. J attaches the virion to the host receptor LamB, inducing viral DNA ejection. This domain, which determines the host specificity of the phage, shows an immunoglobulin-like fold [[cite:PUB00155963],[cite:PUB00109155]]. Many of the proteins in this entry are annotated as fibronectin type III. This domain was previously known as DUF3672 and is normally found associated with [pfam:PF09327] and [pfam:PF13550].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00109155":{"PMID":10629200,"ISBN":null,"volume":"182","issue":"2","year":2000,"title":"The C-terminal portion of the tail fiber protein of bacteriophage lambda is responsible for binding to LamB, its receptor at the surface of Escherichia coli K-12.","URL":null,"raw_pages":"508-12","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Wang J","Hofnung M","Charbit A."],"DOI_URL":null},"PUB00155963":{"PMID":38760367,"ISBN":null,"volume":"15","issue":"1","year":2024,"title":"Structural mechanism of bacteriophage lambda tail's interaction with the bacterial receptor.","URL":null,"raw_pages":"4185","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Ge X","Wang J."],"DOI_URL":"https://doi.org/10.1038/s41467-024-48686-3"}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":91,"pathways":0,"proteins":91,"proteomes":58,"sets":1,"structural_models":{"alphafold":54},"structures":9,"taxa":172},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":79},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}