{"metadata":{"accession":"PF12400","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022127","hierarchy":null,"name":{"name":"STIMATE family","short":"STIMATE"},"description":[{"text":"<p>STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch [[cite:PUB00076888]]. This entry also includes  budding yeast YPL162C.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00076888":{"PMID":26322679,"ISBN":null,"volume":"17","issue":"10","year":2015,"title":"Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca(2+) influx.","URL":null,"raw_pages":"1339-47","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Jing J","He L","Sun A","Quintana A","Ding Y","Ma G","Tan P","Liang X","Zheng X","Chen L","Shi X","Zhang SL","Zhong L","Huang Y","Dong MQ","Walker CL","Hogan PG","Wang Y","Zhou Y."],"DOI_URL":"http://dx.doi.org/10.1038/ncb3234"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":63,"interactions":0,"matches":4139,"pathways":0,"proteins":4107,"proteomes":2598,"sets":0,"structural_models":{"alphafold":3588},"structures":0,"taxa":6732},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":101,"alignment:full":3435},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}