T4BSS_DotH_IcmK is a family of bacterial transporter proteins from Proteobacteria. DotH is an integral outer membrane component and it may form an outer membrane complex along with DotD and DotC functionally equivalent to secretins. DotH is the strongest candidate for the VirB9 counterpart of other T4BSS systems [[cite:PUB00075640]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Type_IV_secretion#Secretion_in_Gram_negative_bacteria","extract":"Secretion is the movement of material from one point to another, such as a secreted chemical substance from a cell or gland. In contrast, excretion is the removal of certain substances or waste products from a cell or organism. The classical mechanism of cell secretion is via secretory portals at the plasma membrane called porosomes. Porosomes are permanent cup-shaped lipoprotein structures embedded in the cell membrane, where secretory vesicles transiently dock and fuse to release intra-vesicular contents from the cell.
","thumbnail":null}],"literature":{"PUB00075640":{"PMID":21743810,"ISBN":null,"volume":"2","issue":null,"year":2011,"title":"Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria.","URL":null,"raw_pages":"136","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Nagai H","Kubori T."],"DOI_URL":"http://dx.doi.org/10.3389/fmicb.2011.00136"}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":378,"pathways":0,"proteins":371,"proteomes":317,"sets":1,"structural_models":{"alphafold":250},"structures":14,"taxa":643},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":133},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}