{"metadata":{"accession":"PF12281","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR058575","hierarchy":null,"name":{"name":"Nucleotidyltransferase","short":"NTP_transf_8"},"description":[{"text":"<p>This is a family of bacterial proteins that have a nucleotidyltransferase fold. The fold-prediction is backed up by conservation of three highly characteristic sequence motifs found in all other nucleotidyl transferases: i) pDhDhhh(h/p), where p is a polar residue and h is a hydrophobic residue; ii) upstream of the first, a GG/S; iii) a conserved D/E in a hydrophobic surround. In the classification of nucleotidyltransferases proposed in [[cite:PUB00066751]] this is a group XVIII NTP-transferase. Many of these sequences were classified in the COG database as COG5397. The exact function is not known.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00066751":{"PMID":19833706,"ISBN":null,"volume":"37","issue":"22","year":2009,"title":"Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human.","URL":null,"raw_pages":"7701-14","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Kuchta K","Knizewski L","Wyrwicz LS","Rychlewski L","Ginalski K."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gkp854"}},"set_info":{"accession":"CL0260","name":"NTP_transf"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":982,"pathways":0,"proteins":980,"proteomes":841,"sets":1,"structural_models":{"alphafold":635},"structures":0,"taxa":1524},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":557},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}