{"metadata":{"accession":"PF12257","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048255","hierarchy":null,"name":{"name":"Vacuolar membrane-associated protein Iml1, vWA-like domain","short":"vWA_IML1"},"description":[{"text":"<p>Proteins in this entry contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy [[cite:PUB00063317],[cite:PUB00063319]]. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy [[cite:PUB00063318]]. This is a vWA-like domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00063318":{"PMID":21900499,"ISBN":null,"volume":"22","issue":"21","year":2011,"title":"Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation.","URL":null,"raw_pages":"4124-33","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Wu X","Tu BP."],"DOI_URL":"http://dx.doi.org/10.1091/mbc.E11-06-0525"},"PUB00063317":{"PMID":21454883,"ISBN":null,"volume":"10","issue":"6","year":2011,"title":"A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae.","URL":null,"raw_pages":"M110.006478","medline_journal":"Mol Cell Proteomics","ISO_journal":"Mol. Cell Proteomics","authors":["Dokudovskaya S","Waharte F","Schlessinger A","Pieper U","Devos DP","Cristea IM","Williams R","Salamero J","Chait BT","Sali A","Field MC","Rout MP","Dargemont C."],"DOI_URL":"http://dx.doi.org/10.1074/mcp.M110.006478"},"PUB00063319":{"PMID":21804352,"ISBN":null,"volume":"7","issue":"11","year":2011,"title":"A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation.","URL":null,"raw_pages":"1392-3","medline_journal":"Autophagy","ISO_journal":"Autophagy","authors":["Dokudovskaya S","Rout MP."],"DOI_URL":"http://dx.doi.org/10.4161/auto.7.11.17347"}},"set_info":{"accession":"CL0128","name":"vWA-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":128,"interactions":0,"matches":4910,"pathways":0,"proteins":4843,"proteomes":2798,"sets":1,"structural_models":{"alphafold":619},"structures":15,"taxa":7363},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":96,"alignment:full":3805},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}