This domain is found at the C-terminal end of the probable enoyl -CoA hydratase alpha subunit from Thermomonospora curvata (ChsH2) and similar archaeal and bacterial proteins. ChsH2 is likely to be involved in bile acid degradation. The C-terminal region of this protein is organised into two domains: an N-terminal zinc finger domain with a three-stranded antiparallel beta-sheet and an N-terminal alpha-helix (this entry) and a OB-fold domain ([pfam:PF01796]) [[cite:PUB00155451]]. The domain is duplicated in some members like [swissprot:O53566] from M.tuberculosis. The structure of [swissprot:Q97WQ4] from Saccharolobus solfataricus reveals two long N-terminal helices followed by a rubredoxin -like zinc ribbon domain represented in this family and a C-terminal OB fold domain [[cite:PUB00097287]]. Zinc is chelated by the four conserved cysteines in the alignment.
","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00159949":{"PMID":31804766,"ISBN":null,"volume":"10","issue":"2","year":2020,"title":"Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus.","URL":null,"raw_pages":"221-228","medline_journal":"FEBS Open Bio","ISO_journal":"FEBS Open Bio","authors":["Kaiser M","Wurm JP","Martens B","Blasi U","Pogoryelov D","Wohnert J."],"DOI_URL":"https://doi.org/10.1002/2211-5463.12772"},"PUB00159916":{"PMID":30318713,"ISBN":null,"volume":"20","issue":"1","year":2019,"title":"Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase.","URL":null,"raw_pages":"88-95","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Pavkov-Keller T","Schmidt NG","Zadlo-Dobrowolska A","Kroutil W","Gruber K."],"DOI_URL":"https://doi.org/10.1002/cbic.201800462"},"PUB00154878":{"PMID":29531083,"ISBN":null,"volume":"115","issue":"13","year":2018,"title":"Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.","URL":null,"raw_pages":"3380-3385","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Vogeli B","Engilberge S","Girard E","Riobe F","Maury O","Erb TJ","Shima S","Wagner T."],"DOI_URL":"https://doi.org/10.1073/pnas.1718649115"},"PUB00155451":{"PMID":31209106,"ISBN":null,"volume":"294","issue":"31","year":2019,"title":"The steroid side-chain-cleaving aldolase Ltp2-ChsH2DUF35 is a thiolase superfamily member with a radically repurposed active site.","URL":null,"raw_pages":"11934-11943","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Aggett R","Mallette E","Gilbert SE","Vachon MA","Schroeter KL","Kimber MS","Seah SYK."],"DOI_URL":"https://doi.org/10.1074/jbc.RA119.008889"},"PUB00097287":{"PMID":20944206,"ISBN":null,"volume":"66","issue":"Pt 10","year":2010,"title":"The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role.","URL":null,"raw_pages":"1160-6","medline_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","ISO_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","authors":["Krishna SS","Aravind L","Bakolitsa C","Caruthers J","Carlton D","Miller MD","Abdubek P","Astakhova T","Axelrod HL","Chiu HJ","Clayton T","Deller MC","Duan L","Feuerhelm J","Grant JC","Han GW","Jaroszewski L","Jin KK","Klock HE","Knuth MW","Kumar A","Marciano D","McMullan D","Morse AT","Nigoghossian E","Okach L","Reyes R","Rife CL","van den Bedem H","Weekes D","Xu Q","Hodgson KO","Wooley J","Elsliger MA","Deacon AM","Godzik A","Lesley SA","Wilson IA."],"DOI_URL":null}},"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":44,"interactions":0,"matches":12166,"pathways":0,"proteins":12165,"proteomes":4066,"sets":1,"structural_models":{"alphafold":7456},"structures":15,"taxa":5926},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":76,"alignment:full":5884},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}