{"metadata":{"accession":"PF12157","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022591","hierarchy":null,"name":{"name":"Protein of unknown function (DUF3591)","short":"DUF3591"},"description":[{"text":"<p>This domain is found in eukaryotes and is typically between 445 to 462 amino acids in length. Most members are annotated as being transcription initiation factor TFIID subunit 1, and this region is the conserved central portion of these proteins.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0662","name":"Triple_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":140,"interactions":0,"matches":5429,"pathways":0,"proteins":5144,"proteomes":3243,"sets":1,"structural_models":{"alphafold":1665},"structures":30,"taxa":8558},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":79,"alignment:full":4167},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}