{"metadata":{"accession":"PF12148","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021991","hierarchy":null,"name":{"name":"Tandem tudor domain within UHRF1","short":"TTD"},"description":[{"text":"<p>TTD, tandem tudor domain within UHRF1 preferentially binds H3 histone tails trimethylated at Lys-9. It specifically recognises H3 tail peptides with the heterochromatin-associated modification state of trimethylated lysine 9 and unmodified lysine 4 (H3K4me0/K9me3). This domain is found in eukaryotes and is found in association with [pfam:PF00097], [pfam:PF02182], [pfam:PF00628], [pfam:PF00240].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00059694":{"PMID":21489993,"ISBN":null,"volume":"286","issue":"27","year":2011,"title":"Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.","URL":null,"raw_pages":"24300-11","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Nady N","Lemak A","Walker JR","Avvakumov GV","Kareta MS","Achour M","Xue S","Duan S","Allali-Hassani A","Zuo X","Wang YX","Bronner C","Chedin F","Arrowsmith CH","Dhe-Paganon S."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M111.234104"},"PUB00069841":{"PMID":14741369,"ISBN":null,"volume":"557","issue":"1-3","year":2004,"title":"NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.","URL":null,"raw_pages":"209-14","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett.","authors":["Mori T","Li Y","Hata H","Kochi H."],"DOI_URL":"http://dx.doi.org/10.1016/S0014-5793(03)01495-9"}},"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":42,"interactions":0,"matches":2573,"pathways":0,"proteins":2551,"proteomes":973,"sets":1,"structural_models":{"alphafold":2263},"structures":27,"taxa":3282},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":29,"alignment:full":2052},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6b9m","name":"Crystal structure of UHRF1 TTD domain in complex with the polybasic region"}}}