{"metadata":{"accession":"PF12141","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021988","hierarchy":null,"name":{"name":"Beta-mannosyltransferases","short":"BMT"},"description":[{"text":"<p>This entry represents a group of fungal beta-mannosyltransferase that are involved in cell wall biosynthesis [[cite:PUB00086020]]. For example, in Candida albicans, BMT1-4 enzymes act stepwise to add beta-mannoses on to cell-wall phosphopeptidomannan (PPM). While Bmt5 and Bmt6 are involved in the addition of the first and third beta-mans to phospholipomannan (PLM), respectively [[cite:PUB00097617]]. Furthermore, in Saccharomyces cerevisiae, BMT5 and BMT6 are responsible for methylation of uridine residues in the 25S rRNA [[cite:PUB00075659]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086020":{"PMID":18234669,"ISBN":null,"volume":"283","issue":"15","year":2008,"title":"Identification of a new family of genes involved in beta-1,2-mannosylation of glycans in Pichia pastoris and Candida albicans.","URL":null,"raw_pages":"9724-36","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Mille C","Bobrowicz P","Trinel PA","Li H","Maes E","Guerardel Y","Fradin C","Martinez-Esparza M","Davidson RC","Janbon G","Poulain D","Wildt S."],"DOI_URL":"https://doi.org/10.1074/jbc.M708825200"},"PUB00097617":{"PMID":22745283,"ISBN":null,"volume":"22","issue":"10","year":2012,"title":"Members 5 and 6 of the Candida albicans BMT family encode enzymes acting specifically on β-mannosylation of the phospholipomannan cell-wall glycosphingolipid.","URL":null,"raw_pages":"1332-42","medline_journal":"Glycobiology","ISO_journal":"Glycobiology","authors":["Mille C","Fradin C","Delplace F","Trinel PA","Masset A","Francois N","Coddeville B","Bobrowicz P","Jouault T","Guerardel Y","Wildt S","Janbon G","Poulain D."],"DOI_URL":null},"PUB00075659":{"PMID":24335083,"ISBN":null,"volume":"42","issue":"5","year":2014,"title":"Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae.","URL":null,"raw_pages":"3246-60","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Sharma S","Yang J","Duttmann S","Watzinger P","Kotter P","Entian KD."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gkt1281"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":14,"interactions":0,"matches":808,"pathways":0,"proteins":525,"proteomes":154,"sets":0,"structural_models":{"alphafold":429},"structures":0,"taxa":389},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":50,"alignment:full":579},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}