{"metadata":{"accession":"PF12126","entry_id":null,"type":"coiled_coil","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021978","hierarchy":null,"name":{"name":"PML-like, coiled-coil","short":"PML_CC"},"description":[{"text":"<p>This is the coiled-coil region of PML, also known as TRIM19. PML acts in association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, such as tumour, suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. PML is defined by the TRIM/RBCC motif which consists of an N-terminal RING zinc finger, two BBox type zinc fingers followed by a coiled-coil region [[cite:PUB00102048]]. This coiled-coil region is thought to mediate interactions with cytomegalovirus IE1 protein and/or other partners [[cite:PUB00102048]]. This entry also includes RNF207, which has a similar organisation.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00102048":{"PMID":28250117,"ISBN":null,"volume":"91","issue":"10","year":2017,"title":"The ND10 Component Promyelocytic Leukemia Protein Acts as an E3 Ligase for SUMOylation of the Major Immediate Early Protein IE1 of Human Cytomegalovirus. ","URL":null,"raw_pages":"e02335-16","medline_journal":"J Virol","ISO_journal":"J Virol","authors":["Reuter N","Schilling EM","Scherer M","Muller R","Stamminger T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":72,"interactions":0,"matches":1358,"pathways":0,"proteins":1276,"proteomes":427,"sets":0,"structural_models":{"alphafold":1093},"structures":11,"taxa":1440},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":16,"alignment:full":1120},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6uyr","name":"Crystal structure of K46-acetylated SUMO1 in complex with PML-SIM"}}}