This family of bacterial proteins includes the outer membrane lipoprotein Flpp3 from Francisella tularensis ([swissprot:Q5NF33]). Flpp3, a virulence determinant of tularemia, shows a six stranded beta-sheet supported with two crossing alpha-helices. It has a hydrophobic internal cavity that has been suggested to bind a small organic molecule. However, its specific function is still unknown [[cite:PUB00100865],[cite:PUB00100866]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00100866":{"PMID":32142641,"ISBN":null,"volume":"28","issue":"5","year":2020,"title":"XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia.","URL":null,"raw_pages":"540-547.e3","medline_journal":"Structure","ISO_journal":"Structure","authors":["Zook J","Shekhar M","Hansen D","Conrad C","Grant T","Gupta C","White T","Barty A","Basu S","Zhao Y","Zatsepin N","Ishchenko A","Batyuk A","Gati C","Li C","Galli L","Coe J","Hunter M","Liang M","Weierstall U","Nelson G","James D","Stauch B","Craciunescu F","Thifault D","Liu W","Cherezov V","Singharoy A","Fromme P."],"DOI_URL":null},"PUB00100865":{"PMID":26004443,"ISBN":null,"volume":"23","issue":"6","year":2015,"title":"NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins.","URL":null,"raw_pages":"1116-22","medline_journal":"Structure","ISO_journal":"Structure","authors":["Zook J","Mo G","Sisco NJ","Craciunescu FM","Hansen DT","Baravati B","Cherry BR","Sykes K","Wachter R","Van Horn WD","Fromme P."],"DOI_URL":null}},"set_info":{"accession":"CL0545","name":"APCOP-app_sub"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":298,"pathways":0,"proteins":297,"proteomes":158,"sets":1,"structural_models":{"alphafold":218},"structures":3,"taxa":414},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":132},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6pny","name":"X-ray Structure of Flpp3"}}}