{"metadata":{"accession":"PF12070","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022709","hierarchy":null,"name":{"name":"Protein SCAI","short":"SCAI"},"description":[{"text":"<p>SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity.  It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional  regulation of ITGB1 [[cite:PUB00068364]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00068364":{"PMID":19350017,"ISBN":null,"volume":"11","issue":"5","year":2009,"title":"SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin.","URL":null,"raw_pages":"557-68","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Brandt DT","Baarlink C","Kitzing TM","Kremmer E","Ivaska J","Nollau P","Grosse R."],"DOI_URL":"http://dx.doi.org/10.1038/ncb1862"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":51,"interactions":0,"matches":3823,"pathways":0,"proteins":3464,"proteomes":1682,"sets":0,"structural_models":{"alphafold":2971},"structures":0,"taxa":5209},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":2820},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}