This is the central region of eukaryotic SOX17 and 18 transcription factor proteins [[cite:PUB00078726]]. It lies just downstream of the HMG-box family, [pfam:PF00505], and is followed by a C-terminal domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"SOX_gene_family","extract":"SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box. This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species.
","thumbnail":null}],"literature":{"PUB00078726":{"PMID":10549281,"ISBN":null,"volume":"4","issue":"4","year":1999,"title":"Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin.","URL":null,"raw_pages":"487-98","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Zorn AM","Barish GD","Williams BO","Lavender P","Klymkowsky MW","Varmus HE."],"DOI_URL":"http://dx.doi.org/10.1016/S1097-2765(00)80200-2"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":1909,"pathways":0,"proteins":1906,"proteomes":722,"sets":0,"structural_models":{"alphafold":1654},"structures":0,"taxa":2212},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":27,"alignment:full":1523},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}