{"metadata":{"accession":"PF12066","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021933","hierarchy":null,"name":{"name":"SERRATE/Ars2, N-terminal domain","short":"SERRATE_Ars2_N"},"description":[{"text":"<p>This domain can be found in the N terminus of the SERRATE (SE) from plants and its homologue, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe [[cite:PUB00090022]]. This domain has two completely conserved Y residues that may be functionally important.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00090022":{"PMID":29703953,"ISBN":null,"volume":"9","issue":"1","year":2018,"title":"Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.","URL":null,"raw_pages":"1701","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Schulze WM","Stein F","Rettel M","Nanao M","Cusack S."],"DOI_URL":"https://doi.org/10.1038/s41467-018-04142-7"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":74,"interactions":0,"matches":4550,"pathways":0,"proteins":4526,"proteomes":2693,"sets":0,"structural_models":{"alphafold":3779},"structures":7,"taxa":7319},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":44,"alignment:full":3294},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}