{"metadata":{"accession":"PF12064","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021931","hierarchy":null,"name":{"name":"Protein kinase C-binding protein 1","short":"DUF3544"},"description":[{"text":"<p>This is a domain found predominantly in eukaryotes and associated with [pfam:PF00628] [pfam:PF01753] [pfam:PF00439] [pfam:PF00855]. Family members include protein kinase C-binding protein 1 (also known as ZMYND8) which acts as a transcriptional corepressor of the H3K4 demethylase JARID1D [[cite:PUB00085454]]. ZMYND8 (zinc finger and MYND [myeloid, Nervy, and DEAF-1] domain containing 8) binds acetylated damaged chromatin, including actively transcribed regions, as a means of recruiting the nucleosome remodeling and histone deacetylation (NuRD) chromatin remodeling complex for transcriptional repression and DNA double-strand break (DSB) repair by homologous recombination (HR) [[cite:PUB00103635]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00103635":{"PMID":25593309,"ISBN":null,"volume":"29","issue":"2","year":2015,"title":"Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.","URL":null,"raw_pages":"197-211","medline_journal":"Genes Dev","ISO_journal":"Genes Dev","authors":["Gong F","Chiu LY","Cox B","Aymard F","Clouaire T","Leung JW","Cammarata M","Perez M","Agarwal P","Brodbelt JS","Legube G","Miller KM."],"DOI_URL":null},"PUB00085454":{"PMID":27477906,"ISBN":null,"volume":"63","issue":"3","year":2016,"title":"ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.","URL":null,"raw_pages":"470-84","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Li N","Li Y","Lv J","Zheng X","Wen H","Shen H","Zhu G","Chen TY","Dhar SS","Kan PY","Wang Z","Shiekhattar R","Shi X","Lan F","Chen K","Li W","Li H","Lee MG."],"DOI_URL":"https://doi.org/10.1016/j.molcel.2016.06.035"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":30,"interactions":0,"matches":3369,"pathways":0,"proteins":3284,"proteomes":702,"sets":0,"structural_models":{"alphafold":2827},"structures":0,"taxa":2145},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":2711},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}