{"metadata":{"accession":"PF12058","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021926","hierarchy":null,"name":{"name":"PII-interacting protein X","short":"PipX"},"description":[{"text":"<p>This protein family includes PII-interacting protein X (PipX) from Synechococcus elongatus and similar proteins found in cyanobacteria. PipX modulates the expression of genes involved in nitrogen assimilation by interacting with the global nitrogen transcription factor NtcA and the signal transduction protein PII. It is involved in several regulatory pathways [[cite:PUB00100697]]. The crystal structure of this protein shows a tudor-like domain (TLD), formed by a highly bent beta-sheet that mediates the interactions with both PII and NtcA, and two C-terminal helices [[cite:PUB00054483]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100697":{"PMID":24912181,"ISBN":null,"volume":"111","issue":"23","year":2014,"title":"PipX, the coactivator of NtcA, is a global regulator in cyanobacteria.","URL":null,"raw_pages":"E2423-30","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Espinosa J","Rodriguez-Mateos F","Salinas P","Lanza VF","Dixon R","de la Cruz F","Contreras A."],"DOI_URL":null},"PUB00054483":{"PMID":20716687,"ISBN":null,"volume":"107","issue":"35","year":2010,"title":"Structural basis for the regulation of NtcA-dependent transcription by proteins PipX and PII.","URL":null,"raw_pages":"15397-402","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Llacer JL","Espinosa J","Castells MA","Contreras A","Forchhammer K","Rubio V."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1007015107"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":248,"pathways":0,"proteins":248,"proteomes":237,"sets":0,"structural_models":{"alphafold":147},"structures":5,"taxa":642},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":34,"alignment:full":209},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3n5b","name":"The complex of PII and PipX from Anabaena"}}}