{"metadata":{"accession":"PF12038","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022701","hierarchy":null,"name":{"name":"tRNA-queuosine alpha-mannosyltransferase N-terminal","short":"QTMAN_N"},"description":[{"text":"<p>This is the N-terminal domain of tRNA-queuosine alpha-mannosyltransferase (QTMAN, also known as GTDC1) from animals. QTMAN is a glycosyltransferase that specifically catalyses mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)) to form mannosyl-queuosine(34) [[cite:PUB00153407]]. Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation at cognate codons GAC and GAU, thereby regulating protein translation [[cite:PUB00153407]]. This domain is about 170 amino acids in length and adopts a Rossmann-fold. This domain is found associated with [pfam:PF00534] found at the C-terminal. This domain has two conserved sequence motifs: HENQ and FNS and it also has a single completely conserved residue S that may be functionally important. This domain is also found in uncharacterised bacterial sequences.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153407":{"PMID":37992713,"ISBN":null,"volume":"186","issue":"25","year":2023,"title":"Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.","URL":null,"raw_pages":"5517-5535.e24","medline_journal":"Cell","ISO_journal":"Cell","authors":["Zhao X","Ma D","Ishiguro K","Saito H","Akichika S","Matsuzawa I","Mito M","Irie T","Ishibashi K","Wakabayashi K","Sakaguchi Y","Yokoyama T","Mishima Y","Shirouzu M","Iwasaki S","Suzuki T","Suzuki T."],"DOI_URL":"https://doi.org/10.1016/j.cell.2023.10.026"}},"set_info":{"accession":"CL0113","name":"GT-B"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":21,"interactions":0,"matches":2313,"pathways":0,"proteins":2272,"proteomes":1429,"sets":1,"structural_models":{"alphafold":1894},"structures":0,"taxa":4073},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":37,"alignment:full":1715},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}