{"metadata":{"accession":"PF12037","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021911","hierarchy":null,"name":{"name":"ATPase family AAA domain-containing protein 3, N-terminal","short":"ATAD3_N"},"description":[{"text":"<p>This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerisation [[cite:PUB00097486]] and interacts with the inner surface of the outer mitochondrial membrane [[cite:PUB00089261]]. This domain is found associated with the AAA ATPase domain ([pfam:PF00004]). ATAD3 is essential for mitochondrial network organisation, mitochondrial metabolism and cell growth at organism and cellular level. It may also play an important role in mitochondrial protein synthesis.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00089261":{"PMID":20154147,"ISBN":null,"volume":"30","issue":"8","year":2010,"title":"The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes.","URL":null,"raw_pages":"1984-96","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Gilquin B","Taillebourg E","Cherradi N","Hubstenberger A","Gay O","Merle N","Assard N","Fauvarque MO","Tomohiro S","Kuge O","Baudier J."],"DOI_URL":"https://doi.org/10.1128/MCB.00007-10"},"PUB00097486":{"PMID":22664726,"ISBN":null,"volume":"12","issue":"4","year":2012,"title":"ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.","URL":null,"raw_pages":"441-8","medline_journal":"Mitochondrion","ISO_journal":"Mitochondrion","authors":["Merle N","Feraud O","Gilquin B","Hubstenberger A","Kieffer-Jacquinot S","Assard N","Bennaceur-Griscelli A","Honnorat J","Baudier J."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":69,"interactions":0,"matches":3759,"pathways":0,"proteins":3619,"proteomes":1805,"sets":0,"structural_models":{"alphafold":3101},"structures":0,"taxa":5566},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":27,"alignment:full":2807},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}