This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily [[cite:PUB00085069]], which are distant members of the GPCR superfamily.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00085069":{"PMID":21733186,"ISBN":null,"volume":"6","issue":null,"year":2011,"title":"CREST--a large and diverse superfamily of putative transmembrane hydrolases.","URL":null,"raw_pages":"37","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Pei J","Millay DP","Olson EN","Grishin NV."],"DOI_URL":"https://doi.org/10.1186/1745-6150-6-37"}},"set_info":{"accession":"CL0192","name":"GPCR_A"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":51,"interactions":0,"matches":4599,"pathways":0,"proteins":4473,"proteomes":1621,"sets":1,"structural_models":{"alphafold":3868},"structures":5,"taxa":5007},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":3506},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}