{"metadata":{"accession":"PF12031","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR033388","hierarchy":null,"name":{"name":"SWI/SNF-like complex subunit BAF250/Osa","short":"BAF250_C"},"description":[{"text":"<p>This entry represents the mammalian BAF250a/b and its homologue osa from fruit flies [[cite:PUB00071661]]. They are part of the  SWI/SNF-like ATP-dependent chromatin remodelling  complex that regulates gene expression through regulating  nucleosome remodelling. In humans there are two BAF250 isoforms, BAF250a/ARID1a and BAF250b/ARID1b. BAF250a/b may be E3 ubiquitin ligases that target histone H2B [[cite:PUB00071658]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00071661":{"PMID":11124806,"ISBN":null,"volume":"14","issue":"24","year":2000,"title":"Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes.","URL":null,"raw_pages":"3140-52","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Collins RT","Treisman JE."],"DOI_URL":"http://dx.doi.org/10.1101/gad.854300"},"PUB00071658":{"PMID":20086098,"ISBN":null,"volume":"30","issue":"7","year":2010,"title":"Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.","URL":null,"raw_pages":"1673-88","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Li XS","Trojer P","Matsumura T","Treisman JE","Tanese N."],"DOI_URL":"http://dx.doi.org/10.1128/MCB.00540-09"}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":26,"interactions":0,"matches":5040,"pathways":0,"proteins":4970,"proteomes":1548,"sets":1,"structural_models":{"alphafold":629},"structures":6,"taxa":4911},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":3798},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}