{"metadata":{"accession":"PF12026","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021901","hierarchy":null,"name":{"name":"Crk-Associated Substrate C-terminal domain","short":"CAS_C"},"description":[{"text":"<p>This is a C-terminal domain found in CAS family members. The CAS (Crk-Associated Substrate) protein family is a group of scaffolding proteins that play important modulatory roles in both normal and pathological cell growth regulation. They contain an N-terminal Src homology 3 (SH3) domain [pfam:PF00018] and a substrate domain (SD). The SD contains a large number of YxxP motifs, which when phosphorylated by Src-family kinases provide canonical binding sites for proteins containing SH2 domains such as Crk, Crk-L, CRKII presumed domain is functionally uncharacterised [[cite:PUB00069470]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00069470":{"PMID":19937461,"ISBN":null,"volume":"67","issue":"7","year":2010,"title":"CAS proteins in normal and pathological cell growth control.","URL":null,"raw_pages":"1025-48","medline_journal":"Cell Mol Life Sci","ISO_journal":"Cell. Mol. Life Sci.","authors":["Tikhmyanova N","Little JL","Golemis EA."],"DOI_URL":"http://dx.doi.org/10.1007/s00018-009-0213-1"}},"set_info":{"accession":"CL0705","name":"VBS-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":44,"interactions":0,"matches":4939,"pathways":0,"proteins":4918,"proteomes":1182,"sets":1,"structural_models":{"alphafold":4372},"structures":2,"taxa":3860},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":29,"alignment:full":4015},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}