{"metadata":{"accession":"PF12018","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021897","hierarchy":null,"name":{"name":"Domain of unknown function","short":"FAP206"},"description":[{"text":"<p>This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found FAP206 [swissprot:Q23H79], a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule [[cite:PUB00082324]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00082324":{"PMID":25540426,"ISBN":null,"volume":"26","issue":"4","year":2015,"title":"FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein c.","URL":null,"raw_pages":"696-710","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Vasudevan KK","Song K","Alford LM","Sale WS","Dymek EE","Smith EF","Hennessey T","Joachimiak E","Urbanska P","Wloga D","Dentler W","Nicastro D","Gaertig J."],"DOI_URL":"http://dx.doi.org/10.1091/mbc.E14-11-1506"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":28,"interactions":0,"matches":1641,"pathways":0,"proteins":1601,"proteomes":1224,"sets":0,"structural_models":{"alphafold":1404},"structures":1,"taxa":4024},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":41,"alignment:full":1307},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}