{"metadata":{"accession":"PF12013","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022698","hierarchy":null,"name":{"name":"Orsellinic acid/F9775 biosynthesis cluster protein D","short":"OrsD"},"description":[{"text":"<p>This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 247 to 1018 amino acids in length. Family members include orsellinic acid/F9775 biosynthesis cluster protein D (orsD) from Emericella nidulans. The orsD gene is part of the cluster that encodes components for the biosynthesis of orsellinic acid, as well as biosynthesis of the cathepsin K inhibitors F9775 A and F9775 B [[cite:PUB00083127]] [[cite:PUB00083128]], but the function of orsD is unknown. OrsD contains two segments that are likely to be C2H2 zinc binding domains.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00083128":{"PMID":20174687,"ISBN":null,"volume":"6","issue":"3","year":2010,"title":"Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans.","URL":null,"raw_pages":"587-93","medline_journal":"Mol Biosyst","ISO_journal":"Mol Biosyst","authors":["Sanchez JF","Chiang YM","Szewczyk E","Davidson AD","Ahuja M","Elizabeth Oakley C","Woo Bok J","Keller N","Oakley BR","Wang CC."],"DOI_URL":"http://dx.doi.org/10.1039/b904541d"},"PUB00083127":{"PMID":19666480,"ISBN":null,"volume":"106","issue":"34","year":2009,"title":"Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.","URL":null,"raw_pages":"14558-63","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Schroeckh V","Scherlach K","Nutzmann HW","Shelest E","Schmidt-Heck W","Schuemann J","Martin K","Hertweck C","Brakhage AA."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0901870106"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":58,"interactions":0,"matches":2142,"pathways":0,"proteins":2099,"proteomes":608,"sets":0,"structural_models":{"alphafold":1473},"structures":0,"taxa":1505},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":2028},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}