This family includes members found in bacteria, fungi and archaea, many of which are ice-binding proteins (IBPs) [[cite:PUB00094907]]. In Antarctic bacterium Flavobacterium frigoris PS1, FfIBP is an ice-binding protein that inhibits ice growth through direct interaction with ice crystals to permit the survival of polar organisms in extremely cold environments [[cite:PUB00089804]]. In arctic yeast Leucosporidium sp, LeIBP, an ice-binding protein, can lower the freezing point below the melting point once it binds to ice [[cite:PUB00058444]]. Family members also have a single completely conserved glycine residue that may be functionally important.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Antifreeze_protein","extract":"Antifreeze proteins (AFPs) or ice structuring proteins refer to a class of polypeptides produced by certain animals, plants, fungi and bacteria that permit their survival in temperatures below the freezing point of water. AFPs bind to small ice crystals to inhibit the growth and recrystallization of ice that would otherwise be fatal. There is also increasing evidence that AFPs interact with mammalian cell membranes to protect them from cold damage. This work suggests the involvement of AFPs in cold acclimatization.
","thumbnail":null}],"literature":{"PUB00058444":{"PMID":22303017,"ISBN":null,"volume":null,"issue":null,"year":2012,"title":"Structural basis for the antifreeze activity of an ice-binding protein from an Arctic yeast.","URL":null,"raw_pages":null,"medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Lee JH","Park AK","Do H","Park KS","Moh SH","Chi YM","Kim HJ."],"DOI_URL":null},"PUB00094907":{"PMID":30680879,"ISBN":null,"volume":"286","issue":"5","year":2019,"title":"Ice-binding proteins and the 'domain of unknown function' 3494 family.","URL":null,"raw_pages":"855-873","medline_journal":"FEBS J","ISO_journal":"FEBS J.","authors":["Vance TDR","Bayer-Giraldi M","Davies PL","Mangiagalli M."],"DOI_URL":null},"PUB00089804":{"PMID":24699650,"ISBN":null,"volume":"70","issue":"Pt 4","year":2014,"title":"Structure-based characterization and antifreeze properties of a hyperactive ice-binding protein from the Antarctic bacterium Flavobacterium frigoris PS1.","URL":null,"raw_pages":"1061-73","medline_journal":"Acta Crystallogr D Biol Crystallogr","ISO_journal":"Acta Crystallogr. D Biol. Crystallogr.","authors":["Do H","Kim SJ","Kim HJ","Lee JH."],"DOI_URL":"https://doi.org/10.1107/S1399004714000996"}},"set_info":{"accession":"CL0847","name":"Ice_binding"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":158,"interactions":0,"matches":2427,"pathways":0,"proteins":2322,"proteomes":1257,"sets":1,"structural_models":{"alphafold":1582},"structures":25,"taxa":2377},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":49,"alignment:full":1521},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4nuh","name":"Crystal structure of mLeIBP, a capping head region swapped mutant of ice-binding protein"}}}