{"metadata":{"accession":"PF11979","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022557","hierarchy":null,"name":{"name":"Smad anchor for receptor activation-like, C-terminal","short":"SARA_C"},"description":[{"text":"<p>This domain is found at the C-terminal end of a group of animal zinc finger FYVE domain-containing proteins, including Smad anchor for receptor activation (SARA), which plays a significant role in TGF-mediated signalling. This domain is involved in the interaction with the TGF-beta receptor [[cite:PUB00042868],[cite:PUB00024191]]. This domain is found associated with [pfam:PF01363].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00042868":{"PMID":9865696,"ISBN":null,"volume":"95","issue":"6","year":1998,"title":"SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.","URL":null,"raw_pages":"779-91","medline_journal":"Cell","ISO_journal":"Cell","authors":["Tsukazaki T","Chiang TA","Davison AF","Attisano L","Wrana JL."],"DOI_URL":"http://dx.doi.org/10.1016/S0092-8674(00)81701-8"},"PUB00024191":{"PMID":10615055,"ISBN":null,"volume":"287","issue":"5450","year":2000,"title":"Structural basis of Smad2 recognition by the Smad anchor for receptor activation.","URL":null,"raw_pages":"92-7","medline_journal":"Science","ISO_journal":"Science","authors":["Wu G","Chen YG","Ozdamar B","Gyuricza CA","Chong PA","Wrana JL","Massague J","Shi Y."],"DOI_URL":"http://dx.doi.org/10.1126/science.287.5450.92"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":42,"interactions":0,"matches":3678,"pathways":0,"proteins":3470,"proteomes":1225,"sets":0,"structural_models":{"alphafold":1641},"structures":1,"taxa":3946},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":2922},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}