{"metadata":{"accession":"PF11963","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022570","hierarchy":null,"name":{"name":"Betacoronavirus, lineage A, NSP1","short":"B-CoV_A_NSP1"},"description":[{"text":"<p>This family the N-terminal region of the Betacoronavirus polyprotein which contains non-structural protein 1 (Nsp1) from Betacoronavirus lineage A. This protein is important for viral replication and pathogenesis [[cite:PUB00094116],[cite:PUB00097618]]. It suppresses the host innate immune functions by inhibiting type I interferon expression and host antiviral signalling pathways.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00094116":{"PMID":25432065,"ISBN":null,"volume":"202","issue":null,"year":2015,"title":"Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression.","URL":null,"raw_pages":"89-100","medline_journal":"Virus Res","ISO_journal":"Virus Res.","authors":["Narayanan K","Ramirez SI","Lokugamage KG","Makino S."],"DOI_URL":null},"PUB00097618":{"PMID":30568804,"ISBN":null,"volume":"4","issue":"2","year":2018,"title":"Identification and characterization of Coronaviridae genomes from Vietnamese bats and rats based on conserved protein domains.","URL":null,"raw_pages":"vey035","medline_journal":"Virus Evol","ISO_journal":"Virus Evol","authors":["Phan MVT","Ngo Tri T","Hong Anh P","Baker S","Kellam P","Cotten M."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":184,"pathways":0,"proteins":165,"proteomes":6,"sets":0,"structural_models":{"alphafold":11},"structures":0,"taxa":73},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":15},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}